The TGA (Therapeutic Goods Administration) has issued a warning to pregnant women and those planning pregnancy of the link between non-aspirin anti-inflammatory medications and miscarriage. Common medications include ibuprofen ( nurofen), diclofenac ( voltaren), mefenamic acid (ponstan) and naproxen ( naprogesic).

A review of the medical literature has demonstrated a link, especially if the medicine is taken close to the time of conception. The TGA has proposed changing warnings on all non-aspirin anti-inflammatories to "do not use if likely to become pregnant, or during the first six months of pregnancy except on doctor's advice. Do not use at all during the last three months of pregnancy".

A large Canadian study from 2011 demonstrated twice as many miscarriages in those taking the medications as those who were not.

The Committee advised that there was not sufficient evidence to change the current advice on the use of aspirin.

There are many other individual factors that can increase the risk of miscarriage, including increasing maternal age, smoking, obesity and other medical conditions.

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